Modeling time-to-cure from severe acute malnutrition: application of various parametric frailty models

Modeling time-to-cure from severe acute malnutrition: application of various parametric frailty models

BACKGROUND In developing countries about 3.5% of children aged 0-5 years are victims of severe acute malnutrition (SAM). Once the morbidity has developed the cure process takes variable period depending on various factors. Knowledge of time-to-cure from SAM will enable health care providers to plan resources and monitor the progress of cases with SAM. The current analysis presents modeling time...

Possible Risk Factors Related to Malnutrition in 6-59-Month Children with Severe Acute Malnutrition in District Pakpattan, Punjab

Background: Malnutrition is responsible for one third of the mortality rate among children less than 5 years old. Worldwide, 54% of the child deaths are due to malnutrition and the caseload in Pakistan is equal to 46%. In the current study, we attempted to identify the possible risk factors related to malnutrition among6-59-month children in Pakpattan, Punjab province. Methods: A total of 500 s...

Bayesian cure rate frailty models with application to a root canal therapy study.

Due to natural or artificial clustering, multivariate survival data often arise in biomedical studies, for example, a dental study involving multiple teeth from each subject. A certain proportion of subjects in the population who are not expected to experience the event of interest are considered to be "cured" or insusceptible. To model correlated or clustered failure time data incorporating a ...

Management of severe acute malnutrition.

Assessing the fit of parametric cure models.

Survival data can contain an unknown fraction of subjects who are "cured" in the sense of not being at risk of failure. We describe such data with cure-mixture models, which separately model cure status and the hazard of failure among non-cured subjects. No diagnostic currently exists for evaluating the fit of such models; the popular Schoenfeld residual (Schoenfeld, 1982. Partial residuals for...